The focus is on the study of processes of living objects on a molecular-physical level. The possibility to address these questions is due to newly developed experimental techniques such as optical and scanning probe techniques. In addition molecular biology is providing excellent materials control which allows selecting suitable experimental systems for collaboration between biologists and physicists. The combination with microlithography creates possibilities for unique experimental research as well as for lab-on-a-chip ideas. In addition, the strong Life Sciences activities at Leiden University enable collaborative projects.