Peter Zijlstra, Pedro Paulo and Michel Orrit detect “invisible” proteins one-by-one (20-4-2012)


The conventional way to detect individual proteins in an optical microscope is to measure their absorption or fluorescence. This leaves many proteins undetectable, because they do not absorb or fluoresce at a useful wavelength. In an article in Nature Nanotechnology Zijlstra and coworkers show that a single gold particle can act as a messenger to report the binding and unbinding of individual proteins.

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