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Lecture 1: Biocompatibility - Kees Kluft (GBS; moderator)

Medical devices and biotech/nano-products show adverse reactions in the body.

• -- One of the practical answers is to select material with minimal impact
• -- There are blood and plasma tests to evaluate rapid reactions in clotting, inflammation and induction of pain
• -- Further improvement and validation of the test panel may predict better the reactions and help to select artificial materials for minimal effects.

Lecture 2: Blood clotting - Joost Meijers (Sanquin)

Medical device thrombosis costs the U.S. healthcare system an estimated $1 billion annually with over 50,000 deaths per year caused by thromboembolism.

• -- One of the practical answers is to suppress reactions using antithrombotic therapy
• -- Bleeding is a serious side effect of 'old' and 'novel' antithrombotic therapy
• -- There is a new theory how to break the inevitable link between bleeding and thrombosis
• -- Future improvements concern efficacious antithrombotic therapy without side effect of bleeding

Lecture 3: Grow your own blood vessel - Joris Rotmans (LUMC)

A theoretical perfect solution would be to develop our own body material

• -- How to use the human body as in vivo bioreactor ?
• -- The promise of bioincompatible polymers
• -- Blood pressure and flow as the driving force for tissue differentiation

From 17:00 hrs: panel discussion and drinks