Bionanoscience (BN) seminar by dr. David Maresca (Imaging Physics department, Delft University of Technology) on "4D Sound Sheet Imaging of Genetically Encoded Acoustic Reporters".  The talk will start at 12:45h, and lunch is provided from 12:30h.

Abstract: Successive advances in light sheet fluorescence microscopy now enable fast, large-volume, and high resolution imaging of fluorescently labelled cells in transparent organisms. However, limitations inherent to optical methods (optical penetration depth < 1 mm) prevent large scale imaging in intact and opaque organisms, and these limitations are more pronounced in instances where high speed (~ 1 ms) is desirable.

Biomolecular ultrasound is an emerging field that combines engineering of acoustic biomolecules with advanced ultrasound imaging methods. Biomolecular ultrasound enables noninvasive imaging of whole organs with a unique combination of spatial coverage (~ cm scale) and spatiotemporal resolution (~ 100 μm and 1 ms, respectively). As such, the development of 4D sound sheet imaging of opaque tissue using acoustic reporters that directly link acoustic contrast with biological function could redefine our capacity to observe biology at work.