Nuclear spins are only slightly aligned even in the strong magnetic fields of superconducting magnets because the magnetic energy of nuclear spin is much smaller than thermal energy. This is the major reason for the difficulty of initializing nuclear spin qubits  and the low sensitivity of MRI. Using electron spins in thermal equilibrium, which have 660 times higher magnetic energy, the sensitivity can be enhanced by at most this factor through dynamic nuclear polarization (DNP). Utilizing photo-excited triplet electrons of pentacene molecule instead, we demonstrate much larger enhancement factor at room temperature, which will make MRI hyper-sensitive and nuclear spin qubits initialized for quantum simulation & computation.