PROGRAM

BN Seminar - Ian McRae (Scripps Institute, USA): "Mechanisms of gene-regulation by microRNAs"

Date:

Time:

16:00 hrs

Location:

A1.100, building 58, TU Delft

 

Abstract
MicroRNAs (miRNAs) are major regulators of gene expression in plants and animals. These small RNAs function within RNA-protein complexes to silence messenger RNAs targeted for repression. We have determined structures of the human proteins Argonaute-2 and TNRC6, two core components of miRNA-silencing complexes. Our results provide insights into how miRNAs identify target RNAs, and specifically sequester them for degradation.

Events

Workshops

29 March 2011 - 1 January 2021

Casimir Course - Hot Topicslink