PROGRAM

Prof. Omar Saleh (Univ. of California): "DNA-based active gels"

Date:

Time:

11 AM

Location:

TU Delft, BN conference room

 

Prof. Omar Saleh from the University of California, Santa Barbara, will visit  TU Delft and at 11 a.m. in the BN conference room he will discuss: "DNA-based active gels".

You are all invited to attend!

Abstract:

Cells are capable of a variety of dramatic stimuli-responsive mechanical behaviors. These capabilities are enabled by the pervading cytoskeletal network, an active gel composed of cross-linked structural filaments (e.g. actin) that are acted upon by motor proteins (e.g. myosin). I will discuss our efforts to replicate these features using non-cytoskeletal components, and thus to create artificial active gels. Such systems could be useful as models for understanding the physics of active fluctuations within the cytoskeleton and/or the nucleus. In particular, I will describe the synthesis and characterization of a gel formed from self-assembled DNA filaments, and activated by DNA motor proteins. The DNA gel stiffens upon activation, and displays non-equilibrium, yet quasi-diffusive, dynamics. Both features match theory and measurements of the cytoskeleton, highlighting  the universal aspects of non-equilibrium, motor-driven networks.

Workshops

29 March 2011 - 1 January 2021

Casimir Course - Hot Topicslink