PhD

PhD position: Building stochastic models to explore the implication of component exchange for the robust operation of genetic information processing complexes

Description
All life depends on genetic information being accessed and acted upon by a host of molecular machines. Though the machines are nanosized, and thus strongly influenced by thermal noise, they must operate with great precision and robustness in the crowded, stochastic, and changing environment inside cells. Interestingly, the machines themselves are often dynamic in their composition and continuously replace components while performing their biological task. The costs and benefits of such component exchange is not quantitatively understood, and the successful PhD applicant will build stochastic models to explore the implication of component exchange for the robust operation of genetic information processing complexes such as the replisome. Though the work is expected to be mainly analytical, simulations will be used when/if needed. This theoretical project forms part of an otherwise experimental consortium of eight groups, and the research will be performed in close collaboration with experimentalists.  

Requirements
We are looking to hire an outstanding student who is keen to use her/his theoretical skills to model biological systems in collaboration with experimenters. The successful applicant will have the possibility to strongly influence the direction of his/her research. As this is a biophysics project an appreciation of both physics and biology is required. A strong theoretical background in biophysics, physics, or related fields is a must, as is a good command of spoken and written English. 

Information and application
For more information about this position, please contact dr. Martin Depken by e-mail. To apply, please e-mail me a detailed CV and names of two references along with a letter of application by 15 March 2015. When applying for this position, please refer to vacancy number TNWBN15-004.

Start date
No later than September 2015

We are also always open to hosting independently funded PhD and Post Docs!

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